Convening the World's Hearts and Minds to Cure DADA2

We are a global collaborative of patients and families, physicians and researchers. Together, we are dedicated to continually learning about the rare genetic disease, Deficiency of Adenosine Deaminase 2 or DADA2. Together, we will discover new treatments, create helpful resources, and eventually find a cure.

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What is DADA2?

DADA2 - or Deficiency of Adenosine Deaminase 2 - is a rare, autosomal recessive genetic disease that leads to excessive inflammation in several areas of the body, immunodeficiency, and bone marrow failure.

In many cases, this inflammation can lead to mild and chronic symptoms like fevers and rash that mimic other diseases, making it difficult to diagnose. In more severe cases and acute episodes, DADA2 causes vasculitis resulting in debilitating or deadly strokes, immunodeficiency, and even bone marrow failure.

We invite you to get to know DADA2 with this overview video (below) and by visiting the "What is DADA2" page.

Get to Know DADA2 and How We Collaborate

Learn more about what DADA2 is and how it affects patients.  And check out a recap from our latest international conference, held in October 2023.

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150+

Physicians & Researchers Engaged in Discovery

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600+

Patients Known Today
More than 35,000 Undiagnosed

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250+

Papers & Abstracts Published in World-Renowned Journals

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30+

Countries & Institutions Home to Physicians, Researchers & Patients

With You in the Journey

Whether you have just been diagnosed or have navigated living with DADA2 for years, you are on a journey – and we want to be a resource alongside you. We are here with the next steps to help navigate your care with your doctor, your feelings of relief or fear, and your everyday life. As the DADA2 Community, we don’t want you to feel alone.

Patients & Families

Patients and their families are our priority. We know that your experience is a critical part of better understanding DADA2, and that your quality-of-life matters.

Doctors & Researchers

Without a 500+ scientific and clinical community, DADA2 will remain a mystery.  We bring global researchers and doctors together to better understand and treat the disease.

Questions?

We can help clarify.

Contact Us

You Play a Role in the Cure

We believe that everyone plays a role in the quest for a cure.
From contributing to the Patient Registry, to sharing your story, to fundraising and so much more, it will take the efforts and encouragement of everyone whose life is touched by DADA2 to find a cure. Get connected with different ways to contribute to a cure.

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The 2023 Conference

A focused group of DADA2 physicians and researchers from around the world will meet in 2023 to take a deep dive into the most foundational scientific elements of the ADA2 protein and its function. As a global community, we believe this is the next best step we can take to find treatments for DADA2.

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Join the Patient Registry

Your experiences matter to research on DADA2. Learn more about the DADA2 Patient Registry/Natural History Study so that, when it is ready, you can report your symptoms, care, and successes.

Meet Patients Like You

Meet the DADA2 patients, just like the nearly 600 diagnosed around the world, who are featured throughout our website.  

Kelsey, 13

USA

The DADA2 Foundation Community is hope - hope for a cure and a better future for our family.

 

Turchetti Family

Peru

Finding the DADA2 Foundation brought immense relief. We joined a supportive community sharing our concerns and a dedicated medical community pursuing treatments and a cure.

Anna Maria, 25

Italy

Alone we are rare, together we are strong. To fight rare genetic diseases, one must be there wholeheartedly.

 

Andy, 31

USA

I am grateful to have the DADA2 Foundation, and to know there are others out there like me.

 

The Smit Family

South Africa

Being the only diagnosed DADA 2 patient in South Africa was pretty scary, until the DADA 2 foundation took me under their wings with caring, guidance and support.

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Finding Purpose in the Journey: The DADA2 Foundation History

The DADA2 Foundation began when one family’s 10+ year journey finally found an answer in two published papers on a new disease, studied by two different groups around the globe. Since that day in 2014, the DADA2 Foundation has been the go-to resource for physicians, researchers, patients and families looking to collaborate and learn more about the disease.

Stay in the Know

Everyday, physicians, researchers & patients are asking questions to better understand DADA2. Keep up to date on what we're learning throughout the DADA2 Community.

Scientific research is the bedrock of our understanding of DADA2. View the findings of DADA2 researchers here.

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Join our monthly newsletter which highlights work being done around the globe to cure DADA2 and guide patients living with the disease. Visit the newsletter archive to learn more.